Reaktion #66161

Reaktionsgleichung

compound

Ethyl (6-chloropyridin-3-yl)acetate

dimethylformamide diethyl acetal

→

Ethyl 2-(6-chloropyridin-3-yl)-3-(dimethylamino)acrylate

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe mixture is then concentrated on a rotary evaporator
2. 2
   Sonstigethe residue is chromatographed on silica gel 60 (mobile phase: dichloromethane→dichloromethane/methanol 20:1)

Vorschrift

3.99 g (20.0 mmol) of the compound from Example 1A are dissolved in 13.7 ml of dimethylformamide diethyl acetal, and the mixture is stirred with microwave irradiation at 90° C. for 30 min. The mixture is then concentrated on a rotary evaporator, and the residue is chromatographed on silica gel 60 (mobile phase: dichloromethane→dichloromethane/methanol 20:1).

Quelle