Reaktion #661492

Reaktionsgleichung

39b

6-[(2-Piperazin-1-yl-ethyl)-propyl-amino]-5,6,7,8-tetrahydro-naphthalen-1-ol

benzo[b]thiophene-2-carboxylic acid

→

40i

Ausbeute 99.9%

Benzo[b]thiophen-2-yl-(4-{2-[(5-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amino]-ethyl}-piperazin-1-yl)-methanone

Ausbeute 99.9%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeCompound 40i was prepared

Vorschrift

Compound 40i was prepared following Procedure G using 39b (175 mg, 0.551 mmol) and benzo[b]thiophene-2-carboxylic acid (118 mg, 0.661 mmol) to give 40i (263 mg, 64%) after column chromatography. 1H NMR (400 MHz, CD3OD) 0.91-0.97 (t, 3H, J=7.2 Hz), 1.53-1.68 (m, 3H), 2.50-2.63 (m, 7H), 2.78-3.02 (m, 7H), 3.77-3.79 (bs, 4H), 6.55-6.59 (t, 2H, J=8 Hz), 6.89-6.93 (t, 1H, J=8.4 Hz), 7.40-7.46 (m, 2H), 7.61 (s, 1H), 7.85-7.91 (m, 2H). The free base of 40i was converted into its HCl salt. m.p. 131-134° C. Anal. [C28H35N3O2S.2HCl.1.5H2O] C, H, N.

Quelle