Reaktion #66133

Reaktionsgleichung

water

N-bromosuccinimide

benzoyl peroxide

2-chloro-5-methyl-pyridine

→

5-bromomethyl-2-chloro-pyridine

Lösungsmittel

carbon tetrachloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed for 90 min
2. 2
   Sonstigethe organic layer separated
3. 3
   WaschenThe organic layer was washed successively with water, brine
4. 4
   Trocknendried over anhydrous sodium sulfate
5. 5
   Filtrationfiltered

Vorschrift

N-bromosuccinimide (6.1 g, 3.44 mmol) and benzoyl peroxide (218 mg, 0.09 mmol) were added successively to a solution of 2-chloro-5-methyl-pyridine (4.0 g, 3.13 mmol) in carbon tetrachloride (20 mL) and refluxed for 90 min. The reaction mixture was cooled to room temperature, water added and the organic layer separated. The organic layer was washed successively with water, brine, dried over anhydrous sodium sulfate and filtered. The resultant solution of 5-bromomethyl-2-chloro-pyridine was used as such for the next step.

Quelle