Reaktion #66113

Reaktionsgleichung

Methyl-(4-nitro-phenyl)-amine

acrylic acid

sulfuric acid

→

3-[methyl-(4-nitro-phenyl)-amino]-propionic acid

Ausbeute 91.0%

Lösungsmittel

water

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to room temperature
2. 2
   FiltrationThe precipitated solid was filtered
3. 3
   Sonstigedried
4. 4
   Sonstigeto give a crude product which
5. 5
   Sonstigewas purified
6. 6
   Waschenby washing with diethyl ether and pentane

Vorschrift

Methyl-(4-nitro-phenyl)-amine (3.0 g, 19.7 mmol) and acrylic acid (4.06 mL, 59.2 mmol) were added at 0° C. to a solution of concentrated sulfuric acid (2.15 mL, 39.5 mmol) in water (28 mL). The reaction mixture was heated at 80° C. for 30 min, cooled to room temperature and diluted with water. The precipitated solid was filtered and dried to give a crude product which was purified by washing with diethyl ether and pentane, affording 3-[methyl-(4-nitro-phenyl)-amino]-propionic acid (4.0 g, 91%) as a yellow solid.

Quelle