Reaktion #66100

Reaktionsgleichung

2-Bromo-1-(1-bromo-cyclopentyl)-ethanone

α-picoline

→

1-(2-Cyclopent-1-enyl-2-oxo-ethyl)-2-methyl-pyridinium bromide salt

Ausbeute 117.6%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux overnight
2. 2
   Temperaturto cool
3. 3
   Einengenthen concentrated in vacuo
4. 4
   WaschenThe crude mass was washed with 30% ethyl acetate/petroleum ether and diethyl ether

Vorschrift

2-Bromo-1-(1-bromo-cyclopentyl)-ethanone (3.7 g, 13.7 mmol) and α-picoline (1.02 g, 11.0 mmol) in acetone were heated at reflux overnight. The reaction mixture was allowed to cool then concentrated in vacuo. The crude mass was washed with 30% ethyl acetate/petroleum ether and diethyl ether. 1-(2-Cyclopent-1-enyl-2-oxo-ethyl)-2-methyl-pyridinium bromide salt (3.65 g, 94%) was obtained as a semi-solid material and taken for next step without purification.

Quelle