Reaktion #65990

ord-1e2b7f0d2111451c8933d729cd195d29

Reaktionsgleichung

CCOC(=O)Cc1c(C)[nH]c2ccc(OCc3nc4ccccc4s3)cc12
2-methyl-5-(2-benzothiazolylmethoxy)-1H-indole-3-acetic acid ethyl ester
ClCc1ccc(Cl)cc1
4chlorobenzyl chloride
→
Cc1c(CC(=O)O)c2cc(OCc3nc4ccccc4s3)ccc2n1Cc1ccc(Cl)cc1
title compound
Cc1c(CC(=O)O)c2cc(OCc3nc4ccccc4s3)ccc2n1Cc1ccc(Cl)cc1
1-[(4-Chlorophenyl)methyl]-2-methyl-5-(2-benzothiazolylmethoxy)-1H-indole-3-acetic acid

Edukte

CCOC(=O)Cc1c(C)[nH]c2ccc(OCc3nc4ccccc4s3)cc12
2-methyl-5-(2-benzothiazolylmethoxy)-1H-indole-3-acetic acid ethyl ester
ClCc1ccc(Cl)cc1
4chlorobenzyl chloride

Reagenzien

Keine

Lösungsmittel

CO
methanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeRecrystallization from acetonitrile
  2. 2
    Sonstigeaffords white crystals, m.p. 175°-176° C.

Vorschrift

The title compound is prepared according to the method of Example 16 using 2-methyl-5-(2-benzothiazolylmethoxy)-1H-indole-3-acetic acid ethyl ester and 4chlorobenzyl chloride; however, the hydrolysis is carried out in aqueous methanol. Recrystallization from acetonitrile affords white crystals, m.p. 175°-176° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05420289uspto-grants-1995_05