Reaktion #659893

Reaktionsgleichung

2,2,4,4-tetramethyl-1,3-cyclobutanedione

TMPD glycol

potassium carbonate

→

product

Ausbeute 96.0%

3-Hydroxy-2,2,4-trimethylpentyl 2,2,4-trimethyl-3-oxopentanoate

Ausbeute 96.0%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeReaction
2. 2
   Temperaturwas cooled
3. 3
   WaschenOrganic layer was washed 4 times at 70° C
4. 4
   SonstigeToluene removed

Vorschrift

To a 1-liter round bottom flask was charged 2,2,4,4-tetramethyl-1,3-cyclobutanedione (140.2 g, 1.0 moles), TMPD glycol (146.2 g, 1.0 moles) and potassium carbonate (73 g, 0.53 moles). The mixture was heated to 120° C. and held for 4 hours. Reaction was cooled and 200 mL of toluene added. Organic layer was washed 4 times at 70° C. Toluene removed to provide 275 g of product. GC assay of the product was 95.9% (4.6:1 mixture of two major isomers).

Quelle