Reaktion #659584

Reaktionsgleichung

6-bromo-benzo[b]thiophene

N-fluorobenzenesulfonimide

n-butyl lithium

diisopropyl amine

→

product

Ausbeute 33.0%

6-Bromo-2-fluoro-benzo[b]thiophene

Ausbeute 33.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto afford crude product
2. 2
   SonstigePurification by column chromatography on silica gel (100% hexane)

Vorschrift

Using analogous reaction condition and reagents as described Example 20 for the preparation of I-20a, 6-bromo-benzo[b]thiophene (I-25c: 0.5 g, 2.347 mmol) in dry THF was reacted with N-fluorobenzenesulfonimide (1.33 g, 4.22 mmol), n-butyl lithium (1.76 ml, 3.52 mmol), diisopropyl amine (0.57 ml, 3.99 mmol) to afford crude product. Purification by column chromatography on silica gel (100% hexane) afforded 176 mg of the product (33% yield).

Quelle