Reaktion #659555

Reaktionsgleichung

1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one

4-bromo-2-(trifluoromethyl)pyridine

trans-N,N′-dimethylcyclohexane-1,2-diamine

potassium phosphate

→

product

Ausbeute 33.4%

1-(4-cyclopropylpyridin-3-yl)-3-(2-(trifluoromethyl) pyridin-4-yl)imidazolidin-2-one

Ausbeute 33.4%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigereagents and reaction conditions
2. 2
   Sonstigeto afford the crude product
3. 3
   SonstigePurification by preparative HPLC

Vorschrift

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 70 mg, 0.344 mmol) was reacted with 4-bromo-2-(trifluoromethyl)pyridine (93.5 mg, 0.413 mmol) 1,4-dioxane (5 mL), copper iodide (6.5 mg, 0.034 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (4.8 mg, 0.034 mmol) and potassium phosphate (219 mg, 1.034 mmol) to afford the crude product. Purification by preparative HPLC afforded 40 mg of the product (33% yield).

Quelle