Reaktion #659458

Reaktionsgleichung

5-(4-Methyl-5-trifluoromethyl-isoxazol-3-yl)-thiophene-2-carboxylic acid

dimethylamine hydrochloride

→

product

Ausbeute 72.0%

5-(4-Methyl-5-trifluoromethyl-isoxazol-3-yl)-thiophene-2-carboxylic acid dimethylamide

Ausbeute 72.0%

Lösungsmittel

triethylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture was evaporated to a solid
2. 2
   Sonstigethen triturated
3. 3
   Filtrationfiltered with the aid of water

Vorschrift

Prepared from 5-(4-Methyl-5-trifluoromethyl-isoxazol-3-yl)-thiophene-2-carboxylic acid and dimethylamine hydrochloride by the method described in Example 2 Method B utilizing an additional equivalent of triethylamine. The reaction mixture was evaporated to a solid then triturated and filtered with the aid of water to afford product as a colorless solid (110 mg, 72%). 1H NMR (CDCl3) 2.37 (s, 3H), 3.22 (br s, 6H), 7.41 (d, J=4.0, 1H), 7.47 (d, J=4.0, 1H). 13C NMR 7.9, 37.0 (br), 39.8 (br), 114.7, 118.8 (q, J=271), 128.0, 129.7, 131.6, 140.9, 155.7 (q, J=41), 158.0, 163.7. 19F NMR −63.2. LC/MS 6.03 min, [M+1]+ 305.

Quelle