Reaktion #65922

Reaktionsgleichung

2-Acetylfluorene

cycloheptylamine

ethanol

sodium borohydride

→

amine

Ausbeute 25.9%

N-Cycloheptyl-1-(2-fluorenyl)ethylamine

Ausbeute 25.9%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONdistilled under reduced pressure
2. 2
   Extraktionextracted with chloroform (80 ml×2 times)
3. 3
   TrocknenThe organic layer was dried over anhydrous magnesium sulfate
4. 4
   Einengenconcentrated
5. 5
   SonstigeThe residue was then purified by silica gel column chromatography

Vorschrift

2-Acetylfluorene (4.17 g, 20 mmol) and cycloheptylamine (2.38 g, 21 mmol) were heated together at 130° C. for 14 hrs and, then, distilled under reduced pressure. To the residue were added ethanol (20 ml) and sodium borohydride (0.76 g, 20 mmol) and the mixture was stirred at room temperature overnight. The mixture was then diluted with water (100 ml) and extracted with chloroform (80 ml×2 times). The organic layer was dried over anhydrous magnesium sulfate and concentrated. The residue was then purified by silica gel column chromatography to give 1.58 g of the amine compound.

Quelle