Reaktion #65789

Reaktionsgleichung

3,4-diethoxycarbonyl-3-nitro-2-phenyl-6-sulfopyridine

hydrochloric acid

→

title compound

Ausbeute 152.6%

3-Amino-4,5-diethoxycarbonyl-2-phenyl-6-sulfopyridine

Ausbeute 152.6%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was heated
2. 2
   Temperaturunder reflux for 20 minutes
3. 3
   EinengenAfter the reaction mixture was concentrated to dryness

Vorschrift

A mixture of 0.34 g of 3,4-diethoxycarbonyl-3-nitro-2-phenyl-6-sulfopyridine, 0.41 g of reduced iron and 7 ml of ethanol was heated to 60° C., and then 0.5 ml of conc. hydrochloric acid was added. The mixture was heated under reflux for 20 minutes. After the reaction mixture was concentrated to dryness, the residue was subjected to silica gel column chromatography (eluent:chloroform/methanol 5:1), to give 0.24 g of the title compound as pale yellow crystals.

Quelle