Reaktion #65781

Reaktionsgleichung

3,4-diethoxycarbonyl-5-nitro-6-phenyl-2-(tetrazol-1-yl)pyridine

hydrogen

→

title compound

Ausbeute 51.5%

3-Amino-4,5-diethoxycarbonyl-2-phenyl-6-(tetrazol-1-yl)pyridine

Ausbeute 51.5%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter the catalyst was filtered off

Vorschrift

A mixture of 0.36 g of 3,4-diethoxycarbonyl-5-nitro-6-phenyl-2-(tetrazol-1-yl)pyridine, 0.3 g of 10% Pd-C (50% wet) and 30 ml of ethyl acetate was stirred at room temperature for 2 hours in a stream of hydrogen. After the catalyst was filtered off, the reaction mixture was subjected to silica gel column chromatography with chloroform as the eluent, to give 0.172 g of the title compound.

Quelle