Reaktion #65768

ord-98d021ae1c9a43bb964f4d1eb95679d9

Reaktionsgleichung

CC(=O)O
acetic acid
CCOC(=O)c1c(Br)nc(-c2ccccc2)c([N+](=O)[O-])c1C(=O)OCC
2-bromo-3,4-diethoxycarbonyl-5-nitro-6-phenylpyridine
→
CCOC(=O)c1c(Br)nc(-c2ccccc2)c(N)c1C(=O)OCC
3-Amino-6-bromo-4,5-diethoxycarbonyl-2-phenylpyridine

Edukte

CC(=O)O
acetic acid
—
whereto
—
reduced iron
CCOC(=O)c1c(Br)nc(-c2ccccc2)c([N+](=O)[O-])c1C(=O)OCC
2-bromo-3,4-diethoxycarbonyl-5-nitro-6-phenylpyridine

Reagenzien

Keine

Lösungsmittel

CCO
ethanol

Reaktionsbedingungen

Temperatur
60°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.ADDITIONwas added
  2. 2
    Temperaturthe mixture was refluxed for 1 hour

Vorschrift

In 25 ml of ethanol was dissolved 550 mg of 2-bromo-3,4-diethoxycarbonyl-5-nitro-6-phenylpyridine, whereto 0.36 g (5 eq.) of reduced iron was added, followed by heating to 60° C. After 1.5 ml (16 eq.) of acetic acid was added dropwise, the mixture was refluxed for 1 hour.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05420275uspto-grants-1995_05