Reaktion #65752

Reaktionsgleichung

2-amino-3,4-diethoxycarbonyl-6-methylpyridine

sodium nitrite

→

3,4-Diethoxycarbonyl-6-methyl-2-pyridone

Lösungsmittel

hydrochloric acid

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added dropwise to the solution
2. 2
   workup.WAITleft
3. 3
   Sonstigestanding in a refrigerator overnight
4. 4
   FiltrationThe resulting crystals were collected by filtration
5. 5
   SonstigeThe crystals were recrystallized from ethyl acetate
6. 6
   Sonstigeto give colorless plates

Vorschrift

In 90 ml of 2% hydrochloric acid was dissolved 2.52 g (10 mmol) of 2-amino-3,4-diethoxycarbonyl-6-methylpyridine. A solution of 0.83 g (1.2 eq.) of sodium nitrite dissolved in 3 ml of water was added dropwise to the solution. The mixture was stirred at room temperature for 1 hour and left standing in a refrigerator overnight. The resulting crystals were collected by filtration. The crystals were recrystallized from ethyl acetate to give colorless plates.

Quelle