Reaktion #657283

Reaktionsgleichung

1-Methoxy-piperidin-4-one

potassium cyanide

cyclopropylamine

hydrochloric acid

→

4-Cyclopropylamino-1-methoxy-piperidine-4-carbonitrile

Lösungsmittel

water

diethyl ether

water

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwere then added dropwise at 0° C
2. 2
   TemperaturThe reaction mixture was warmed to room temperature
3. 3
   workup.STIRRINGstirred overnight
4. 4
   Sonstigethe layers separated
5. 5
   Extraktionthe aqueous phase thoroughly extracted with diethyl ether
6. 6
   WaschenThe combined organic layers were washed with brine
7. 7
   Trocknendried over sodium sulfate
8. 8
   Sonstigeevaporated
9. 9
   SonstigeThis material was used without further purification in the next step

Vorschrift

To a solution of cyclopropylamine (1.4 ml, 1.14 g, 20.0 mmol) in methanol (20 ml) at 0° C. was added 1N hydrochloric acid (20 ml, 20.0 mmol) dropwise and the mixture was stirred at room temperature for 30 minutes. 1-Methoxy-piperidin-4-one [prepared according to Journal of Organic Chemistry (1961), 26, 1867-74] (2.58 g, 20.0 mmol), followed 10 minutes later by potassium cyanide (1.3 g, 20.0 mmol) in water (10 ml) were then added dropwise at 0° C. The reaction mixture was warmed to room temperature and stirred overnight, diluted with water and diethyl ether, the layers separated and the aqueous phase thoroughly extracted with diethyl ether. The combined organic layers were washed with brine, dried over sodium sulfate and evaporated. Yield: 3.19 g of 4-cyclopropylamino-1-methoxy-piperidine-4-carbonitrile (title compound P5.2) as an oil. This material was used without further purification in the next step.

Quelle