Reaktion #657275

Reaktionsgleichung

[2-(2,6-Dimethyl-piperidin-1-yl)acetylamino]-acetic acid

N-Hydroxysuccinimide

N,N′-Dicyclohexyl-carbodiimide

→

[2-(2,6-Dimethyl-piperidin-1-yl)acetylamino]-acetic acid-(2,5-dioxo-pyrrolidine-1-yl)-ester

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe solution was filtered
2. 2
   Sonstigethe filtrate was evaporated in vacuo to dryness
3. 3
   workup.DISSOLUTIONThe residue was dissolved in 50 mL dichloromethane
4. 4
   workup.ADDITIONtreated with charcoal
5. 5
   FiltrationAfter filtration
6. 6
   Sonstigethe solution was evaporated in vacuo to dryness
7. 7
   Sonstigethe product was recrystallised from ethyl acetate

Vorschrift

4.54 g (20 mMol) [2-(2,6-Dimethyl-piperidin-1-yl)acetylamino]-acetic acid (30) were added to 2.30 g (20 mMol) N-Hydroxysuccinimide and 4.12 g (20 mMol) N,N′-Dicyclohexyl-carbodiimide dissolved in 150 ml dichloromethane. The reaction mixture was stirred for 16 h at room temperature. The solution was filtered and the filtrate was evaporated in vacuo to dryness. The residue was dissolved in 50 mL dichloromethane and treated with charcoal. After filtration, the solution was evaporated in vacuo to dryness and the product was recrystallised from ethyl acetate.

Quelle