Reaktion #657262

ord-d4bd87fbd14f4d59b5abaf5b8b648ead

Reaktionsgleichung

CCOC(=O)CN(CCn1nc(COC)cc1COC)CCn1nc(COC)cc1COC
ethyl 2-(bis(2-(3,5-bis(methoxymethyl)-1H-pyrazol-1-yl)ethyl)amino)acetate
[Al+3].[H-].[H-].[H-].[H-].[Li+]
LiAlH4
→
COCc1cc(COC)n(CCN(CCO)CCn2nc(COC)cc2COC)n1
title compound
Ausbeute 60.0%
COCc1cc(COC)n(CCN(CCO)CCn2nc(COC)cc2COC)n1
2-(bis(2-(3,5-bis(methoxymethyl)-1H-pyrazol-1-yl)ethyl)amino)ethanol
Ausbeute 60.0%

Edukte

CCOC(=O)CN(CCn1nc(COC)cc1COC)CCn1nc(COC)cc1COC
ethyl 2-(bis(2-(3,5-bis(methoxymethyl)-1H-pyrazol-1-yl)ethyl)amino)acetate
[Al+3].[H-].[H-].[H-].[H-].[Li+]
LiAlH4

Reagenzien

Keine

Lösungsmittel

C1CCOC1
THF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThis compound has been obtained

Vorschrift

This compound has been obtained by reacting a solution of ethyl 2-(bis(2-(3,5-bis(methoxymethyl)-1H-pyrazol-1-yl)ethyl)amino)acetate (280 mg; 0.6 mmol) in dry THF (10 mL) with LiAlH4. The title compound was isolated following the same methodology above described for the synthesis of other (hydroxymethyl)pyrazoles (see example 6). Yield: 60% (170 mg, 0.4 mmol).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09023315B2uspto-grants-2015_05