Reaktion #657260

Reaktionsgleichung

trimethyl-3,4,5-pyrazoletricarboxylate

pyrazole

sodium hydride

trityl chloride

→

title compound

Ausbeute 90.0%

Trimethyl 1-trityl-3,4,5-pyrazoletricarboxylate

Ausbeute 90.0%

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe synthesis of this compound
2. 2
   SonstigeAfter removal of the solvent under vacuum
3. 3
   Waschenthe resulting residue was washed with distilled water, n-hexane
4. 4
   Sonstigefinally dried under vacuum

Vorschrift

The synthesis of this compound was done by tritylation of trimethyl-3,4,5-pyrazoletricarboxylate (1680 mg, 6.94 mmol) using a procedure similar to the one described in examples 2 and 3 for the synthesis of other tritylated pyrazole derivatives. The starting pyrazole reacted with sodium hydride (405 mg, 10.13 mmol) in dry dimethylformamide (80 mL) for 30 min at room temperature. Then, trityl chloride (1935 mg, 6.94 mmol) was added and the reaction mixture stirred overnight at room temperature. After removal of the solvent under vacuum, the resulting residue was washed with distilled water, n-hexane, and finally dried under vacuum to afford the title compound, as a white microcrystalline solid. Yield: 90% (3.034 g, 6.26 mmol).

Quelle