Reaktion #657257

Reaktionsgleichung

1-trityl-4-ethoxymethylpyrazole

→

4-ethoxymethylpyrazole

Ausbeute 44.0%

Lösungsmittel

ethanol acetone

HCl

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added to the resulting solution
2. 2
   TemperaturAfter cooling to room temperature
3. 3
   Filtrationthe reaction mixture was filtered
4. 4
   Waschenwashed with dichloromethane
5. 5
   Extraktionextracted with dichloromethane
6. 6
   Trocknendried over MgSO4
7. 7
   Sonstigethe solvent was evaporated under vacuum

Vorschrift

1-trityl-4-ethoxymethylpyrazole (1.800 g, 4.88 mmol) was dissolved in a mixture of ethanol/acetone (15 ml/5 ml) and 30 mL of 2N HCl was added to the resulting solution. The mixture was heated at 80° C. for 2 h. After cooling to room temperature, the reaction mixture was filtered and washed with dichloromethane. The aqueous layer was basified with 2N NaOH and extracted with dichloromethane. The organic layers were combined, dried over MgSO4 and the solvent was evaporated under vacuum yielding compound 4-ethoxymethylpyrazole as a white oil. Yield: 44% (270 mg, 2.14 mmol).

Quelle