Reaktion #656990

Reaktionsgleichung

7-chloro-2H-3,1-benzoxazine-2,4(1H)dione

4-bromo-2-fluorobenzylamine

→

2-amino-N-(4-bromo-2-fluorobenzyl)-4-chlorobenzamide

Ausbeute 79.9%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 15 minutes
2. 2
   TemperaturAfter cooling
3. 3
   Sonstigetetrahydrofuran was evaporated
4. 4
   Sonstigeto give a residue
5. 5
   SonstigeRecrystallization from isopropyl ether

Vorschrift

A mixture of 7-chloro-2H-3,1-benzoxazine-2,4(1H)dione (18.4 g) and 4-bromo-2-fluorobenzylamine (26 g) in tetrahydrofuran (200 ml) was refluxed for 15 minutes. After cooling, tetrahydrofuran was evaporated to give a residue. Recrystallization from isopropyl ether gave 2-amino-N-(4-bromo-2-fluorobenzyl)-4-chlorobenzamide (26.6 g).

Quelle