Reaktion #6566

Reaktionsgleichung

KOH

ethanol

dibenzyl 2-(3,4,4-trifluoro-3-butenyl)-malonate

→

2-(3,4,4-Trifluoro-3-butenyl)malonic acid

Lösungsmittel

water

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter heating
2. 2
   Temperaturunder reflux for 4 hours
3. 3
   Waschenwashed with ether
4. 4
   Extraktionextracted 4 times with ether
5. 5
   TrocknenThe organic phase was dried over sodium sulphate
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated in a rotary evaporator

Vorschrift

5.56 g (99 mmol) KOH flakes were dissolved in 6.82 ml water and 13.65 ml ethanol and then treated with 11.12 g (28.34 mmol) of dibenzyl 2-(3,4,4-trifluoro-3-butenyl)-malonate. After heating under reflux for 4 hours, the reaction mixture was poured into 30 ml water and washed with ether. The aqueous phase was acidified with dilute hydrochloric acid and extracted 4 times with ether. The organic phase was dried over sodium sulphate, filtered and then concentrated in a rotary evaporator.

Quelle