Reaktion #65643

Reaktionsgleichung

2-(Phenylmethyl)propenoic acid

1-(2-methoxyphenyl)piperazine

propanol

→

product

2-{1-[4-(2-Methoxyphenyl)piperazinyl]methyl}-3-benzenepropanoic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for 18 hours
2. 2
   Sonstigeevaporated in vacuo
3. 3
   SonstigeThe residue was triturated with acetone and ether

Vorschrift

2-(Phenylmethyl)propenoic acid (Mannich and Ganz, Chem. Ber., 1922, 55, 34867) (2.00 g, 12.35 mmol) and 1-(2-methoxyphenyl)piperazine (2.37 g, 12.35 mmol) in propanol (25 ml) were heated under reflux for 18 hours, cooled to room temperature, and evaporated in vacuo. The residue was triturated with acetone and ether to give the product (0.80 g) as a colourless powder, m.p. 155°-158°. (Found: C, 71.6; H, 7.4; N, 7.6. C21H26N2O3 requires C, 71.2; H, 7.3; N, 7.9%.)

Quelle