Reaktion #65632

ord-8e88240b57da42d69ecdb18994186b06

Reaktionsgleichung

Clc1ccc2c(c1)N=Cc1ccccc1O2
8-chloro-dibenz[b,f]-[1,4]oxazepine
O=C1OC(=O)c2ccccc21
phthalic anhydride
→
O=C(O)c1ccccc1C(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21
title compound
Ausbeute 70.3%
O=C(O)c1ccccc1C(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21
2-[(8-chlorodibenz[b,f][1,4]oxazepin-10(11H)-yl)carbonyl]benzoic acid
Ausbeute 70.3%

Edukte

Clc1ccc2c(c1)N=Cc1ccccc1O2
8-chloro-dibenz[b,f]-[1,4]oxazepine
O=C1OC(=O)c2ccccc21
phthalic anhydride

Reagenzien

Keine

Lösungsmittel

C1CCOC1
THF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturwas heated
  2. 2
    Temperaturto reflux for 4 days
  3. 3
    EinengenThe mixture was concentrated
  4. 4
    Sonstigethe residue was triturated with ether
  5. 5
    FiltrationThe precipitated solid was filtered

Vorschrift

A stirred mixture of 8-chloro-dibenz[b,f]-[1,4]oxazepine (3.35 g) and phthalic anhydride (2.13 g) in THF (40 mL) was heated to reflux for 4 days. The mixture was concentrated and the residue was triturated with ether. The precipitated solid was filtered to give the title compound as a white solid (3.84 g).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05420270uspto-grants-1995_05