Reaktion #65598

Reaktionsgleichung

3-chloro-4-(4-chloro-1-naphthoxy)-2,5-dimethylaniline

2-chlorobenzoyl isocyanate

→

1-[3-chloro-4-(4-chloro-1-naphthoxy)-2,5-dimethylpheny 1]-3-(2- chlorobenzoyl)urea

Ausbeute 68.1%

Lösungsmittel

toluene

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas slowly added a solution
2. 2
   Temperaturwas cooled to room temperature
3. 3
   Sonstigeplaced in an ice bath
4. 4
   Filtrationfiltered through a Buchner funnel
5. 5
   SonstigeThe collected solid was dried under vacuum at a temperature of 50° C.

Vorschrift

Into a solution containing 3.0 grams (9.0 mmol) of 3-chloro-4-(4-chloro-1-naphthoxy)-2,5-dimethylaniline prepared in Part B in 25 milliliters of toluene which solution was warmed to a temperature of 50° C. and placed under a nitrogen atmosphere was slowly added a solution containing 2.5 grams (13.8 mmol) of 2-chlorobenzoyl isocyanate in 5 milliters of toluene. After stirring for 1 hour at a temperature of 50° C. the reaction mixture was cooled to room temperature, placed in an ice bath, and filtered through a Buchner funnel. The collected solid was dried under vacuum at a temperature of 50° C. to afford 3.15 grams of 1-[3-chloro-4-(4-chloro-1-naphthoxy)-2,5-dimethylpheny 1]-3-(2- chlorobenzoyl)urea as a white solid having a melting point of 187° C. Elemental analysis of the white solid indicated the following:

Quelle