Reaktion #655812

Reaktionsgleichung

HCl

2,3-dichloroanisole

3,4-dichlorobenzoylchloride

AlCl3

→

2,3-dichloro-4-methoxy-3',4'-dichlorobenzophenone

Lösungsmittel

1,2-dichloroethane

1,2-dichloroethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with CHCl3
2. 2
   WaschenThe resultant organic layer is washed with 10% aqueous K2CO3
3. 3
   Trocknenwater, dried over (Na2SO4)
4. 4
   Sonstigeevaporated

Vorschrift

To a solution of 57.6 g of 3,4-dichlorobenzoylchloride in 1,2-dichloroethane (150 ml) is added 36.7 g of AlCl3 in portions over a 30 minute period. To the resultant mixture is added dropwise 44.26 g of 2,3-dichloroanisole in 1,2-dichloroethane (150 ml). There is an evolution of gas and the reaction mixture is heated to 60° C. for one hour. The mixture is then poured over 150 ml of concentrated HCl and 150 ml of ice and then extracted with CHCl3 and then ethanol. The resultant organic layer is washed with 10% aqueous K2CO3, then water, dried over (Na2SO4) and evaporated to yield 2,3-dichloro-4-methoxy-3',4'-dichlorobenzophenone, mp 113°-140° C.

Quelle