Reaktion #6558

Reaktionsgleichung

(4R-cis)-1,1-dimethylethyl 6-(2-aminoethyl) -2,2-dimethyl-1,3-dioxane-4-acetate

(±)-4-fluoroα-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzenebutaneamide

tetrahydrofuran

ammonium chloride

→

(2R trans)-5 (4-fluorophenyl)-2 (1-methylethyl) -N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide

Lösungsmittel

heptane toluene

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 24 hours
2. 2
   TemperaturThe solution is cooled
3. 3
   SonstigeThe layers are separated
4. 4
   workup.ADDITIONthe organic layer is added to 15 mL of 10% hydrochloric acid solution
5. 5
   workup.ADDITIONTo this solution is added sodium hydroxide (3.6 g)
6. 6
   workup.STIRRINGthe mixture is stirred for 30 hours
7. 7
   workup.ADDITIONby adding 150 mL of water, 90 mL of hexane
8. 8
   Sonstigeseparating the layers
9. 9
   workup.STIRRINGstirred for 3 hours
10. 10
    Extraktionextracted with 150 mL of ethyl acetate
11. 11
    workup.ADDITIONA drop of concentrated hydrochloric acid is added to the ethyl acetate solution
12. 12
    workup.WAITto stand 18 hours
13. 13
    EinengenThe solution is concentrated in vacuo
14. 14
    workup.DISSOLUTIONthe concentrate is redissolved in 50 mL of ethyl acetate
15. 15
    workup.ADDITIONtreated with one drop of concentrated hydrochloric acid
16. 16
    workup.STIRRINGThe solution is stirred 2 hours
17. 17
    Einengenconcentrated in vacuo
18. 18
    workup.DISSOLUTIONdissolved in 3.0 mL of toluene

Vorschrift

A solution of (4R-cis)-1,1-dimethylethyl 6-(2-aminoethyl) -2,2-dimethyl-1,3-dioxane-4-acetate, (Example 2) 2.56 g (9.36 mmol), and (±)-4-fluoroα-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzenebutaneamide mixture of [R-(R*,R*)], [R-(R*,S*)], [S-(R*,R*)], and [S (R*,S*)] isomers (Example 3), 3.00 g (7.20 mmol), in 60 mL of heptane:toluene (9:1) is heated at reflux for 24 hours. The solution is cooled and poured into 300 mL of tetrahydrofuran and 150 mL of saturated ammonium chloride in water. The layers are separated and the organic layer is added to 15 mL of 10% hydrochloric acid solution and the solution is stirred for 15 hours. To this solution is added sodium hydroxide (3.6 g) and the mixture is stirred for 30 hours. The reaction is stopped by adding 150 mL of water, 90 mL of hexane, and separating the layers. The aqueous layer is acidified with dilute hydrochloric acid solution, stirred for 3 hours and extracted with 150 mL of ethyl acetate. A drop of concentrated hydrochloric acid is added to the ethyl acetate solution and the solution is allowed to stand 18 hours. The solution is concentrated in vacuo and the concentrate is redissolved in 50 mL of ethyl acetate and treated with one drop of concentrated hydrochloric acid. The solution is stirred 2 hours, concentrated in vacuo, and dissolved in 3.0 mL of toluene. (2R trans)-5 (4-fluorophenyl)-2 (1-methylethyl) -N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide (2.92 g) is isolated in two crops.

Quelle