Reaktion #655672

Reaktionsgleichung

4(1H-imidazol-1-yl)butanamine dihydrochloride

sodium hydroxide

2-(methylthio)benz[cd]indole hydroiodide

→

desired product

N-[4-(1H-Imidazol-1-yl)butyl]benz[cd]indol-2-amine, monohydroiodide

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThis mixture was heated
2. 2
   Temperaturat reflux for 16 hours
3. 3
   Temperaturcooled to -10° C
4. 4
   SonstigeThe solid was collected
5. 5
   Waschenwashed with ethanol
6. 6
   Trocknenether and dried at 60° C. in vacuo

Vorschrift

A 2.2 g portion 4(1H-imidazol-1-yl)butanamine dihydrochloride and 2 ml of 10N sodium hydroxide in 200 ml of ethanol was stirred for 10 minutes and then treated with 3.2 g of 2-(methylthio)benz[cd]indole hydroiodide. This mixture was heated at reflux for 16 hours and then cooled to -10° C. The mixture was reheated to boiling, clarified while hot and the filtrate cooled to -10° C. The solid was collected, washed with ethanol, then ether and dried at 60° C. in vacuo, giving 2.0 g of the desired product, mp 144°-147° C.

Quelle