Reaktion #65493

ord-0bc925d40dea443fb918fe585560b973

Reaktionsgleichung

CCCCC#CC(=O)c1ccc(Br)cc1
product
CCCCC#CC(=O)c1ccc(Br)cc1
1-(4-bromophenyl) 2-heptyn-1-one
Cc1cc(C)c(S(=O)(=O)[O-])c(C)c1.Cc1cccc[n+]1N
1-amino 2-methylpyridinium 2,4,6-trimethyl-benzene sulfonate
O=C([O-])[O-].[K+].[K+]
potassium carbonate
→
CCCCc1nn2c(C)cccc2c1C(=O)c1ccc(Br)cc1
(4-bromophenyl) (2-butyl 7-methyl pyrazolo(1,5-a) pyridin-3-yl) methanone

Edukte

CCCCC#CC(=O)c1ccc(Br)cc1
product
CCCCC#CC(=O)c1ccc(Br)cc1
1-(4-bromophenyl) 2-heptyn-1-one
Cc1cc(C)c(S(=O)(=O)[O-])c(C)c1.Cc1cccc[n+]1N
1-amino 2-methylpyridinium 2,4,6-trimethyl-benzene sulfonate
O=C([O-])[O-].[K+].[K+]
potassium carbonate

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
dimethylformamide

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

A mixture of 11.4 g of the product of Stage A of Example 1, 250 ml of dimethylformamide and 9.81 g of 1-amino 2-methylpyridinium 2,4,6-trimethyl-benzene sulfonate (Synthesis, 1977, page 1, TAMURA, et al.) and 5.11 g of potassium carbonate were stirred for 5 hours at ambient temperature.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05420138uspto-grants-1995_05