Reaktion #65448

ord-532f46387a1c4e28b58d148e451f20e8

Reaktionsgleichung

Fc1ccc(C(c2ccc(F)cc2)N2CCNCC2)cc1
1-[bis(4-fluorophenyl) methyl]piperazine
CC(C)(C)c1cc2c(cc1O)OCC(C(=O)O)O2
6-hydroxy-7-tert-butyl-2,3-dihydro-1,4-benzodioxin-2-carboxylic acid
→
CC(C)(C)c1cc2c(cc1O)OCC(C(=O)N1CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC1)O2
6-HYDROXY-7-TERT-BUTYL-2-{4-[BIS-(4-FLUOROPHENYL) METHYL]PIPERAZIN-1-YLCARBONYL}-2,3-DIHYDRO-1,4-BENZODIOXIN
Ausbeute 74.0%

Edukte

Fc1ccc(C(c2ccc(F)cc2)N2CCNCC2)cc1
1-[bis(4-fluorophenyl) methyl]piperazine
CC(C)(C)c1cc2c(cc1O)OCC(C(=O)O)O2
6-hydroxy-7-tert-butyl-2,3-dihydro-1,4-benzodioxin-2-carboxylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThat compound is obtained in a yield of 74%

Vorschrift

That compound is obtained in a yield of 74% starting from 1-[bis(4-fluorophenyl) methyl]piperazine and 6-hydroxy-7-tert-butyl-2,3-dihydro-1,4-benzodioxin-2-carboxylic acid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05420132uspto-grants-1995_05