Reaktion #65443

ord-05756995591643b6972f82f5acd7bf95

Reaktionsgleichung

Fc1ccc(C(c2ccc(F)cc2)N2CCNCC2)cc1
1-[bis(4-fluorophenyl)methyl]piperazine
O=C(O)C1=COc2ccc(O)cc2O1
7-hydroxy-1,4-benzodioxin-2-carboxylic acid
→
O=C(C1=COc2ccc(O)cc2O1)N1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1
7-HYDROXY-2-{4-[BIS(4-FLUOROPHENYL)METHYL]PIPERAZIN-1-YLCARBONYL}-1,4-BENZODIOXIN
Ausbeute 76.0%

Edukte

Fc1ccc(C(c2ccc(F)cc2)N2CCNCC2)cc1
1-[bis(4-fluorophenyl)methyl]piperazine
O=C(O)C1=COc2ccc(O)cc2O1
7-hydroxy-1,4-benzodioxin-2-carboxylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThat compound is obtained in a yield of 76%

Vorschrift

That compound is obtained in a yield of 76% starting from 1-[bis(4-fluorophenyl)methyl]piperazine and 7-hydroxy-1,4-benzodioxin-2-carboxylic acid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05420132uspto-grants-1995_05