Reaktion #65430

Reaktionsgleichung

1-chloromethyl-3-methyl-4-phenylthiobenzene

sodium cyanide

→

1-cyanomethyl-3-methyl-4-phenylthiobenzene

Lösungsmittel

brine

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionwas extracted with ethyl acetate (300 ml×3)
2. 2
   WaschenThe extract was washed with saturated brine (200 ml×3)
3. 3
   Trocknendried with anhydrous sodium sulfate
4. 4
   Einengenconcentrated in vacuo

Vorschrift

Thus obtained 1-chloromethyl-3-methyl-4-phenylthiobenzene was dissolved in 56 ml of N,N-dimethylformamide, and 18.16 g of finely ground sodium cyanide was added, and the mixture was stirred overnight at room temperature. After adding 300 ml of saturated brine and 300 ml of ice water to the reaction mixture, it was extracted with ethyl acetate (300 ml×3). The extract was washed with saturated brine (200 ml×3), and dried with anhydrous sodium sulfate, concentrated in vacuo, and 1-cyanomethyl-3-methyl-4-phenylthiobenzene was obtained (45.95 g).

Quelle