Reaktion #653798

Reaktionsgleichung

9H-carbazole-3-carboxylic acid

K2CO3

methyl iodide

→

title compound

Ausbeute 87.5%

9-methylcarbazole-3-carboxylic acid

Ausbeute 87.5%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturunder reflux overnight
3. 3
   Temperaturcooled
4. 4
   Sonstigeevaporated in vacuo
5. 5
   workup.ADDITIONA mixture of the resultant residue and NaOH (170 mg) in aqueous MeOH (90%, 25 mL)
6. 6
   EinengenThe reaction mixture was concentrated
7. 7
   FiltrationThe solids were collected by filtration
8. 8
   Sonstigedried

Vorschrift

A mixture of 9H-carbazole-3-carboxylic acid (300 mg, 1.42 mmol), K2CO3 (800 mg) and methyl iodide (1 mL) in 25 mL of acetone was heated under reflux overnight, then cooled and evaporated in vacuo. A mixture of the resultant residue and NaOH (170 mg) in aqueous MeOH (90%, 25 mL) was stirred at 50° C. for 30 minutes. The reaction mixture was concentrated and acidified with diluted HCl. The solids were collected by filtration and dried to give the title compound (280 mg, 87%).

Quelle