Reaktion #65308

Reaktionsgleichung

6-aminohexan-1-ol

1,2,4-benzenetricarboxylic anhydride

→

1,3-Dioxo-2-(6-hydroxyhex-1-yl)-isoindole-5-carboxylic acid

Lösungsmittel

H2O

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto give a white crystalline solid
2. 2
   FiltrationThe solid was collected by vacuum filtration
3. 3
   Sonstigedried overnight in vacuo
4. 4
   Sonstigeto give 9.1 g (78%) of analytically pure 27

Vorschrift

A mixture of 6-aminohexan-1-ol (11.7 g, 10 mmol) and 1,2,4-benzenetricarboxylic anhydride (7.68 g, 4 mmol) was heated to 175°-225° C. for 15 min or until evolution of H2O vapor stops. The melt was poured into water to give a white crystalline solid. The solid was collected by vacuum filtration and dried overnight in vacuo to give 9.1 g (78%) of analytically pure 27.

Quelle