Reaktion #65306

Reaktionsgleichung

Trifluoroacetic anhydride

2,3,5,6tetrafluorophenol

Boron trifluoride etherate

→

desired product 18

Ausbeute 75.0%

2,3,5,6-Tetrafluorophenyl trifluoroacetate

Ausbeute 75.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was refluxed overnight
2. 2
   workup.DISTILLATIONThe residual solution was distilled at atmospheric pressure
3. 3
   Sonstigeto remove trifluoroacetic anhydride and trifluoroacetic acid

Vorschrift

Trifluoroacetic anhydride (28 mL, 0.2 mol) was added dropwise with stirring to 27.1 g (0,163 mol) of 2,3,5,6tetrafluorophenol. Boron trifluoride etherate (0.2 mL) was added and the mixture was refluxed overnight. The residual solution was distilled at atmospheric pressure to remove trifluoroacetic anhydride and trifluoroacetic acid. The desired product 18 (32.2 g; 75% yield) was collected at 45° C. (18mm) as a colorless liquid:

Quelle