Reaktion #65255

Reaktionsgleichung

2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-carboxaldehyde

2-thienylacetic acid

potassium carbonate

acetic anhydride

→

title compound

(E)-3-[2-n-Butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)-2-propenoic Acid

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe cooled reaction
2. 2
   Sonstigethe solid is separated
3. 3
   Sonstigetriturated several times with ether
4. 4
   Sonstigethe solid is crystallized

Vorschrift

A mixture of 2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-carboxaldehyde (2 mmol), 2-thienylacetic acid (2.3 mmol), potassium carbonate (0.91 mmol), and acetic anhydride (1 mL) is heated gradually to 140° C. and held at this temperature for 6 hours. The cooled reaction is diluted with water and the solid is separated, triturated several times with ether, and the solid is crystallized to give the title compound.

Quelle