Reaktion #652358

Reaktionsgleichung

3,6-bis(dimethylamino)acridine

3,6-bis(dimethylamino)acridine

10-hydroxy-1-bromo decane

→

10-N-(10-hydroxy-1-decyl)-3,6-bis(dimethylamino)acridine

10-N-(10-Hydroxy-1-decyl)-3,6-bis(dimethylamino)acridine bromide salt

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture is heated to reflux
2. 2
   Temperaturthe reaction is cooled

Vorschrift

3,6-bis(dimethylamino)acridine (1.0 millimole) is dissolved in DMF (100 mL) containing 1.1 equivalent of tertiary amine base. To this is added 10-hydroxy-1-bromo decane (1.1 millimole), and the mixture is heated to reflux. When monitoring by TLC shows no remaining 3,6-bis(dimethylamino)acridine, the reaction is cooled and the 10-N-(10-hydroxy-1-decyl)-3,6-bis(dimethylamino)acridine is isolated (0.75 millimoles).

Quelle