Reaktion #65229

ord-d6d39005fa2d48a18b5e64c86310db4f

Reaktionsgleichung

COC(=O)c1ccc2[nH]cc(CCCCBr)c2c1
methyl 3-(4-bromobutyl)indole-5-carboxylate
COc1ccccc1N1CCNCC1
1-(o-methoxyphenyl)piperazine
→
COC(=O)c1ccc2[nH]cc(CCCCN3CCN(c4ccccc4OC)CC3)c2c1
methyl 3-[4-(4-o-methoxyphenylpiperazino)butyl]indole-5-carboxylate

Edukte

COC(=O)c1ccc2[nH]cc(CCCCBr)c2c1
methyl 3-(4-bromobutyl)indole-5-carboxylate
COc1ccccc1N1CCNCC1
1-(o-methoxyphenyl)piperazine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

By reaction of methyl 3-(4-bromobutyl)indole-5-carboxylate with 1-(o-methoxyphenyl)piperazine "B" analogously to Example 1, methyl 3-[4-(4-o-methoxyphenylpiperazino)butyl]indole-5-carboxylate is obtained; hydrate, hydrochloride, m.p. 195°-196°.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05418237uspto-grants-1995_05