Reaktion #652150

Reaktionsgleichung

methyl iodide

methyl 6-indolecarboxylate

sodium hydroxide

→

methyl 1-methyl-6-indolecarboxylate

Ausbeute 86.9%

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Vorschrift

The reaction was carried out in a manner similar to Reference Example 4 except for using 3.00 (17.1 mmol) of methyl 6-indolecarboxylate, 0.68 g (17.1 mmol) of 60% sodium hydroxide, 4.86 g (34.4 mmol) of methyl iodide and 60 ml of dimethylformamide. Thus 2.75 g (86.9%) of methyl 1-methyl-6-indolecarboxylate was obtained.

Quelle