Reaktion #65215

Reaktionsgleichung

1-bromo-3-(2-methylbenzoyl)-5,6,7,8-tetrahydro-2-naphthol

sodium acetate

→

3-(2-methylbenzoyl)-5,6,7,8-tetrahydro-2-naphthol

Ausbeute 96.5%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter the theoretical amount of hydrogen had been absorbed
2. 2
   Filtrationthe catalyst was filtered off
3. 3
   workup.DISTILLATIONThe solvent was then distilled off
4. 4
   workup.ADDITIONthe residue was diluted with water
5. 5
   Extraktionextracted with ethyl acetate
6. 6
   WaschenThe extract was washed with water
7. 7
   Trocknendried (MgSO4)
8. 8
   workup.DISTILLATIONthe solvent was distilled off

Vorschrift

A mixture of 1-bromo-3-(2-methylbenzoyl)-5,6,7,8-tetrahydro-2-naphthol (3.33 g), sodium acetate (0.82 g), 5% palladium-on-carbon (50% hydrate, 1.0 g) and methanol (10 ml) was subjected to catalytic reduction. After the theoretical amount of hydrogen had been absorbed, the catalyst was filtered off. The solvent was then distilled off and the residue was diluted with water and extracted with ethyl acetate. The extract was washed with water and dried (MgSO4) and the solvent was distilled off to give 3-(2-methylbenzoyl)-5,6,7,8-tetrahydro-2-naphthol as an oil (2.45 g, 96.5%).

Quelle