Reaktion #65170

Reaktionsgleichung

Vinyl chloroformate

triethylamine

5-bromo-3-(piperidin-4-ylthio)-1H-indole

→

Vinyl 4-[(5-bromo-1H-indol-3-yl)thio]piperidine-1-carboxylate

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenthe solution is washed with water
2. 2
   TrocknenThe organic phase is dried over magnesium sulfate
3. 3
   Einengenconcentrated

Vorschrift

Vinyl chloroformate (0.75 ml) is added dropwise to a solution of triethylamine (1.2 ml) and 5-bromo-3-(piperidin-4-ylthio)-1H-indole (2.5 g, prepared in Example 49) in dichloromethane (25 ml) at 0° C. After 2 hours at room temperature, the solution is washed with water. The organic phase is dried over magnesium sulfate and concentrated. Vinyl 4-[(5-bromo-1H-indol-3-yl)thio]piperidine-1-carboxylate (1.8 g) is obtained after chromatography on silica gel (eluent: cyclohexane/AcOEt 70/30).

Quelle