Reaktion #65159

Reaktionsgleichung

Sodium methylate

1-methylpiperidine-4-thiol

chloroacetone

→

1-methyl-4-[(2-oxopropyl)thio]piperidine

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe precipitate is filtered off
2. 2
   Einengenthe filtrate is concentrated
3. 3
   Sonstigechromatographed on silica gel (eluent

Vorschrift

Sodium methylate (5.9 g) is added in portions to a solution of 1-methylpiperidine-4-thiol (14 g) in anhydrous tetrahydrofuran (100 ml) at room temperature. After 2 hours at this temperature, chloroacetone (8.8 ml) is added dropwise. After 24 hours, the precipitate is filtered off and the filtrate is concentrated and chromatographed on silica gel (eluent: ethyl acetate, then ethanol) to give 1-methyl-4-[(2-oxopropyl)thio]piperidine (11.5 g) in the form of an oil.

Quelle