Reaktion #65137

Reaktionsgleichung

sodium hydroxide

(2,3-dihydrobenzofuran-5-yl)acetic acid

lithium aluminium hydride

water

Water

→

title compound

5 -(2-Hydroxyethyl)-2,3-dihydrobenzofuran

Lösungsmittel

tetrahydrofuran

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture was filtered
2. 2
   Waschenthe inorganic salts washed with ethyl acetate (2×50 ml)
3. 3
   Einengenconcentrated in vacuo

Vorschrift

A solution of (2,3-dihydrobenzofuran-5-yl)acetic acid (4.9 g - see EP-A-132130) in anhydrous tetrahydrofuran (50 ml) was added dropwise over 10 minutes to a stirred suspension of lithium aluminium hydride (1.57 g) in anhydrous tetrahydrofuran (50 ml) at 0° C. The mixture was allowed to warm to room temperature and stirred for 1 hour. Water (1.5 ml) was cautiously added dropwise followed by 10% aqueous sodium hydroxide (1.5 ml) and, finally, water (4.5 ml). The mixture was filtered and the inorganic salts washed with ethyl acetate (2×50 ml). The filtrate and washings were combined and concentrated in vacuo to give the title compound as an oil, yield 3.3 g.

Quelle