Reaktion #65100

Reaktionsgleichung

4-methoxy-3-fluoro-benzene boronic acid

4-bromo-4'-cyanobiphenyl

sodium carbonate

benzene

→

4-methoxy-3-fluoro-4"-cyano-p-terphenyl

Ausbeute 88.6%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigea solution which was prepared
2. 2
   workup.ADDITIONwas slowly added dropwise
3. 3
   Temperaturto reflux for 8 hours
4. 4
   Temperaturthe solution was cooled
5. 5
   Sonstigethe crystals thus precipitated
6. 6
   Sonstigewere separated by filtration
7. 7
   Waschenwashed with water and methanol in turn
8. 8
   Sonstigedried

Vorschrift

To a mixture of 2.4 g of 4-bromo-4'-cyanobiphenyl, 0.37 g of tetrakis(triphenylphosphine)palladium(0), 15.2 ml of a 2N aqueous sodium carbonate solution, and 19.4 ml of benzene, a solution which was prepared by dissolving 1.9 g of 4-methoxy-3-fluoro-benzene boronic acid synthesized in [1] above in 14.4 ml of ethanol was slowly added dropwise with stirring, and the solution was subjected to reflux for 8 hours. After the reflux was finished, the solution was cooled, and the crystals thus precipitated were separated by filtration and washed with water and methanol in turn, and dried to obtain 2.5 g of 4-methoxy-3-fluoro-4"-cyano-p-terphenyl.

Quelle