Reaktion #650968

Reaktionsgleichung

NaHCO3

(5-bromo-2-fluoro-phenyl)-methanol

phosphorus tribromide

→

title compound

4-Bromo-2-bromomethyl-1-fluoro-benzene

Lösungsmittel

DME

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled to 0° C.
2. 2
   ExtraktionThe solution was extracted with EtOAc
3. 3
   Sonstigethe combined organic layers were dried
4. 4
   Einengenconcentrated
5. 5
   Sonstigepurified by silica gel chromatography

Vorschrift

To (5-bromo-2-fluoro-phenyl)-methanol (1.2 g, 5.9 mmol) in DME (20 mL) was added phosphorus tribromide (0.83 mL, 8.8 mmol), and the reaction was stirred at room temperature for 6 hours. The mixture was cooled to 0° C. and adjusted to pH 6 with saturated aqueous NaHCO3. The solution was extracted with EtOAc, and the combined organic layers were dried, concentrated, and purified by silica gel chromatography to give the title compound.

Quelle