Reaktion #65048

Reaktionsgleichung

N-[4-[2-[2-amino-4,7 -dihydro-4-oxo-3H-pyrrolo[2,3 -d]pyrimidin-5-yl]ethyl]benzoyl]glutamic acid dimethyl ester

sodium hydroxide

hydrochloric acid

→

above product

Ausbeute 59.0%

N-[4-[2-[2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl]ethyl]benzoyl]glutamic acid

Ausbeute 59.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitate was filtered
2. 2
   Waschenwashed with water
3. 3
   Sonstigedried

Vorschrift

A mixture of 0.50 g (1.1 mmol) of N-[4-[2-[2-amino-4,7 -dihydro-4-oxo-3H-pyrrolo[2,3 -d]pyrimidin-5-yl]ethyl]benzoyl]glutamic acid dimethyl ester, prepared in Preparation 5, and 3.3 ml of 2N aqueous sodium hydroxide was stirred at room temperature for 48 hours and neutralized to a pH of 5 with 6M aqueous hydrochloric acid. The precipitate was filtered, washed with water and dried, to give 0.277 g of the above product in a yield of 59 percent.

Quelle