Reaktion #65037

Reaktionsgleichung

1-[5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-2,2-di(phenylthio)-β-D-glycero-pentofuranosyl]uracil

azobisisobutylonitrile

→

1-[5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-2,2-di(phenylthio)-α-D-glycero-pentofuranosyl]uracil

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeTo a solution prepared
2. 2
   workup.ADDITIONwere added
3. 3
   Temperatura reflux
4. 4
   Temperaturunder heating for 48 hours under an argon gas atmosphere
5. 5
   SonstigeAfter completion of the reaction
6. 6
   Sonstigea low boiling point substances were removed by distillation under a reduced pressure so as
7. 7
   Sonstigeto obtain a residue

Vorschrift

To a solution prepared by dissolving 7 mg (0.10 mmol) of 1-[5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-2,2-di(phenylthio)-β-D-glycero-pentofuranosyl]uracil prepared in step (3) in 10 ml of anhydrous benzene, 150 μl (0.57 mmol) of hydrogenated tributyl tin and 10 mg of azobisisobutylonitrile were added, followed by subjecting the resultant solution to a reflux under heating for 48 hours under an argon gas atmosphere. After completion of the reaction, a low boiling point substances were removed by distillation under a reduced pressure so as to obtain a residue.

Quelle