Reaktion #64995

ord-0846063899fa4b59a49b5136ec458cef

Reaktionsgleichung

CCN[C@@H]1CNC[C@H]1SC
trans-3-ethylamino-4-methylthio-pyrrolidine
O=C(O)c1cn(C2CC2)c2c(Cl)c(F)c(F)cc2c1=O
8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
→
CCN[C@@H]1CN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C[C@H]1SC
8-chloro-1-cyclopropyl-7-(trans-3-ethylamino-4-methylthio-1-pyrrolidinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Edukte

CCN[C@@H]1CNC[C@H]1SC
trans-3-ethylamino-4-methylthio-pyrrolidine
O=C(O)c1cn(C2CC2)c2c(Cl)c(F)c(F)cc2c1=O
8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The reaction is carried out analogously to Example 13 with trans-3-ethylamino-4-methylthio-pyrrolidine and 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid to give 8-chloro-1-cyclopropyl-7-(trans-3-ethylamino-4-methylthio-1-pyrrolidinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, melting point: 217°-218° C. (with decomposition).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05416096uspto-grants-1995_05