Reaktion #64957

Reaktionsgleichung

trans-1-benzyl-3-benzylmethylamino-4-methoxy-pyrrolidine

hydrochloric acid

→

trans-4-Methoxy-3-methylamino-pyrrolidine dihydrochloride

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst is filtered off with suction
2. 2
   Einengenthe filtrate is concentrated
3. 3
   Sonstigethe residue is recrystallized from isopropanol/methanol

Vorschrift

9.3 g (29 mmol) of trans-1-benzyl-3-benzylmethylamino-4-methoxy-pyrrolidine are dissolved in 100 ml of methanol, 4.8 ml of concentrated hydrochloric acid are added and the mixture is hydrogenated on 4 g of 10% strength Pd-on-active charcoal at 90° C. under 100 bar. The catalyst is filtered off with suction, the filtrate is concentrated and the residue is recrystallized from isopropanol/methanol.

Quelle