Reaktion #64955

Reaktionsgleichung

3-benzyl-6-oxa-3-azabicyclo[3.1.0]hexane

benzylmethylamine

→

trans-1-Benzyl-3-benzylmethylamino-4-hydroxypyrrolidine

Lösungsmittel

dioxane

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe mixture is extracted with CHCl3
2. 2
   Trocknenthe extracts are dried with K2CO3
3. 3
   Einengenconcentrated
4. 4
   workup.DISTILLATIONdistillation up to 160° C. (oil bath temperature)

Vorschrift

19.4 g (0.1 mol) of 90% strength 3-benzyl-6-oxa-3-azabicyclo[3.1.0]hexane are heated under reflux with 14.5 g (0.12 mol) of benzylmethylamine in 100 ml of dioxane and 200 ml of water overnight. The mixture is extracted with CHCl3, the extracts are dried with K2CO3 and concentrated and the residue is subjected to incipient distillation up to 160° C. (oil bath temperature).

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